Iron oxide-manganese oxide nanoparticles with tunable morphology and switchable MRI contrast mode triggered by intracellular conditions
David García-Soriano, Paula Milán-Rois, Nuria Lafuente-Gómez, Cristina Navío, Lucía Gutiérrez, Lorena Cussó, Manuel Desco, Daniel Calle, Álvaro Somoza, Gorka Salas
Journal of Colloid and Interface Science, 2022
Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control T cell responses
Sara G Dosil, Sheila Lopez-Cobo, Ana Rodriguez-Galan, Irene Fernandez-Delgado, Marta Ramirez-Huesca, Paula Milan-Rois, Milagros Castellanos, Alvaro Somoza, Manuel J Gómez, Hugh T Reyburn, Mar Vales-Gomez, Francisco Sánchez Madrid, Lola Fernandez-Messina
bioRxiv, 2022
Modified Gold Nanoparticles to Overcome the Chemoresistance to Gemcitabine in Mutant p53 Cancer Cells
E García-Garrido, M Cordani, Á Somoza
Pharmaceutics 13 (12), 2067
CRISPR/Cas technology as a promising weapon to
combat viral infections
C Escalona‐Noguero, M López‐Valls, B Sot
BioEssays 43 (4), 2000315
New Approaches to Tackle EMT and Fibrosis: From Epigenetics to Nanotechnology
Cecilia Battistelli, Marco Cordani, Marc Diederich, Álvaro Somoza, Sergio Valente, Raffaele Strippoli
Frontiers in Pharmacology, 2022
Rational Design of Copper (II)–Uracil Nanoprocessed Coordination Polymers to Improve Their Cytotoxic Activity in Biological Media
Verónica G Vegas, Ana Latorre, María Luisa Marcos, Carlos J Gómez-García, Oscar Castillo, Félix Zamora, Jacobo Gómez, José Martínez-Costas, Miguel Vazquez Lopez, Álvaro Somoza, Pilar Amo-Ochoa
ACS Applied Materials & Interfaces 13 (31), 36948-36957
Albumin-based nanostructures for uveal melanoma treatment
Ana Latorre, Alfonso Latorre, Milagros Castellanos, Nuria Lafuente-Gómez, Ciro Rodriguez Diaz, Alejandra Crespo-Barreda, Mercedes Lecea, Marco Cordani, Pilar Martín-Duque, Álvaro Somoza
Nanomedicine: Nanotechnology, Biology and Medicine 35, 102391
Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties
Nuria Lafuente-Gómez, Paula Milán-Rois, David García-Soriano, Yurena Luengo, Marco Cordani, Hernán Alarcón-Iniesta, Gorka Salas, Álvaro Somoza
Cancers 13 (16), 4095
The Role of LncRNAsin Uveal Melanoma
Paula Milán-Rois, Anan Quan, Frank J Slack, Álvaro Somoza
Cancers 13 (16), 4041
Albumin Nanostructures for Nucleic Acid Delivery in Cancer: Current Trend, Emerging Issues, and Possible Solutions
Rama Prajapati, Álvaro Somoza
Cancers 13 (14), 3454
Albumin-Based Nanoparticles for the Delivery of Doxorubicin in Breast Cancer
Rama Prajapati, Eduardo Garcia-Garrido, Álvaro Somoza
Cancers 13 (12), 3011
Novel Cancer Treatments Based on Autophagy Modulation
Marco Cordani, Álvaro Somoza, Marco Tafani, Ilaria Dando, Suresh Kumar
Frontiers in Pharmacology 12
Water soluble iron-based coordination trimers as synergistic adjuvants for pancreatic cancer
Marco Cordani, Esther Resines-Urien, Arturo Gamonal, Paula Milán-Rois, Lionel Salmon, Azzedine Bousseksou, Jose Sanchez Costa, Álvaro Somoza
Antioxidants 10 (1), 66
The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications
David García-Soriano, Rebeca Amaro, Nuria Lafuente-Gómez, Paula Milán-Rois, Álvaro Somoza, Cristina Navío, Fernando Herranz, Lucía Gutiérrez, Gorka Salas
Journal of Colloid and Interface Science 578, 510-521
Tailored functionalized magnetic nanoparticles to target breast cancer cells including cancer stem-like cells
Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L Cortajarena, Bruno M Simões, Alfonso Latorre, Álvaro Somoza, Robert B Clarke, Rodolfo Miranda, Angeles Villanueva
Cancers 12 (6), 1397
Iron Oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: Impact and future perspectives
Susann Piehler, Heidi Dähring, Julia Grandke, Julia Göring, Pierre Couleaud, Antonio Aires, Aitziber L Cortajarena, José Courty, Alfonso Latorre, Álvaro Somoza, Ulf Teichgräber, Ingrid Hilger
Nanomaterials 10 (6), 1016
Boron Dipyrromethene (BODIPY) as Electron‐Withdrawing Group in Asymmetric Copper‐Catalyzed [3+ 2] Cycloadditions for the Synthesis of Pyrrolidine‐Based Biological Sensors
Thomas Rigotti, Juan Asenjo‐Pascual, Ana Martín‐Somer, Paula Milán Rois, Marco Cordani, Sergio Díaz‐Tendero, Álvaro Somoza, Alberto Fraile, Jose Aleman
Advanced Synthesis & Catalysis 362 (6), 1345-1355
Nanomaterials for Autophagy-Related miRNA-34a Delivery in Cancer Treatment
Priyanka Sharma, Ilaria Dando, Raffaele Strippoli, Suresh Kumar, Alvaro Somoza, Marco Cordani, Marco Tafani
Frontiers in Pharmacology 11
Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment
Marco Cordani, Raffaele Strippoli, Álvaro Somoza
Cancers 12 (1), 25
Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells
Ana Latorre, Alfonso Latorre, Milagros Castellanos, Ciro Rodriguez Diaz, Ana Lazaro-Carrillo, Tania Aguado, Mercedes Lecea, Sonia Romero-Pérez, Macarena Calero, José María Sanchez-Puelles, Ángeles Villanueva, Álvaro Somoza
Cancers 11 (7), 969
MicroRNA sensors based on gold nanoparticles
Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment
Marco Cordani, Alvaro Somoza
Cell Mol Life Sci, 2018
Dynamics of Individual Molecular Shuttles Under Mechanical Force
Teresa Naranjo, Kateryna Lemishko, Sd Lorenzo, Alvaro Somoza, Felix Ritort, Emilio Pérez, Borja Ibarra.
Nat. Commun. 9 (1), 4512
Reprogramming Cells for Synergistic Combination Therapy with Nanotherapeutics against Uveal Melanoma
Paula Milán Rois, Alfonso Latorre, Ciro Rodriguez Diaz, Álvaro del Moral, Álvaro Somoza
Biomimetics, 2018, 3, 28.
Uracil grafted imine-based covalent organic framework for nucleobase recognition
Sergio Royuela, Eduardo García-Garrido, Miguel Martín Arroyo, María J Mancheño, María M Ramos, David González-Rodríguez, Álvaro Somoza, Félix Zamora, José L Segura
Chem. Commun., 2018,54, 8729-8732.
Selective G-quadruplex binding by oligoarginine-Ru (dppz) metallopeptides
David Bouzada, Iria Salvadó, Ghofrane Barka, Gustavo Rama, José Martínez-Costas, Romina Lorca, Álvaro Somoza, Manuel Melle-Franco, M Eugenio Vázquez, Miguel Vázquez López
Chem. Commun., 2018,54, 658-661.
Recent advances in uveal melanoma treatment
Beatriz Álvarez‐Rodríguez, Alfonso Latorre, Christian Posch, Álvaro Somoza
Med. Res. Rev. 2017, 37, 1350-1372
Self-assembly of repeat proteins: Concepts and design of new interfaces.
Sanchez-deAlcazar D, Mejias SH, Erazo K, Sot B, Cortajarena AL.
J Struct Biol. 2017
Mechanical measurement of hydrogen bonded host-guest systems under non-equilibrium, near-physiological conditions (Highlighted in Chemistry World)
Teresa Naranjo, Fernando Cerron, Belén Nieto-Ortega, Alfonso Latorre, Álvaro Somoza, Borja Ibarra, Emilio M Perez
Chem. Sci., 2017,8, 6037-604.
Domain topology of human Rasal.
Cuellar J, Valpuesta JM, Wittinghofer A, Sot B.
Biol Chem. 2017
Oligonucleotide Sensor Based on Selective Capture of Upconversion Nanoparticles Triggered by Target-Induced DNA Interstrand Ligand Reaction
Diego Mendez-Gonzalez, Marco Laurenti, Alfonso Latorre, Alvaro Somoza, Ana Vazquez, Ana Isabel Negredo, Enrique López-Cabarcos, Oscar G Calderón, Sonia Melle, Jorge Rubio-Retama
ACS Appl. Mater. Interfaces, 2017, 9, 112272-12281.
The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction.
Sot B, Rubio-Muñoz A, Leal-Quintero A, Martínez-Sabando J, Marcilla M, Roodveldt C, Valpuesta JM.
Sci Rep. 2017;7:40859.
Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers (Highlighted in Biofísica Magazine)
Verónica G Vegas, Romina Lorca, Ana Latorre, Khaled Hassanein, Carlos J Gómez‐García, Oscar Castillo, Álvaro Somoza, Félix Zamora, Pilar Amo‐Ochoa
Angew. Chem. In. Ed. 2017, 56, 987-991.
Molecular chaperones: functional mechanisms and nanotechnological applications.
Fernández-Fernández MR, Sot B, Valpuesta JM.
Nanotechnology. 2016;27(32):324004.
Controlled nanometric fibers of self-assembled designed protein scaffolds.
Mejías SH, Sot B, Guantes R, Cortajarena AL. 2014; 6(19):10982-8.
Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.
Sot B, Behrmann E, Raunser S, Wittinghofer A.
Proc Natl Acad Sci U S A. 2013; 110(1):111-6.
Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence (Highlighted in Biofísica Magazine)
Siamak Javani, Romina Lorca, Alfonso Latorre, Cristina Flors, Aitziber L. Cortajarena, and Álvaro Somoza
ACS Appl. Mater. Interfaces, 2016, 8, 10147–10154.
Modified RNAs in CRISPR/Cas9: An Old Trick Works Again (Highlighted in Biofísica Magazine)
Alfonso Latorre, Ana Latorre, Álvaro Somoza
Angew. Chem. In. Ed. 2016, 55, 3548–3550.
Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.
Antonio Aires, Sandra M Ocampo, Bruno M Simões, María Josefa Rodríguez, Jael F Cadenas, Pierre Couleaud, Katherine Spence, Alfonso Latorre, Rodolfo Miranda, Álvaro Somoza, Robert B Clarke, José L Carrascosa, Aitziber L Cortajarena.
Nanotechnology, 2016, 27, 065103.
Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery
Susanne Kossatz, Julia Grandke, Pierre Couleaud, Alfonso Latorre, Antonio Aires, Kieran Crosbie-Staunton, Robert Ludwig, Heidi Dähring, Volker Ettelt, Ana Lazaro-Carrillo, Macarena Calero, Maha Sader, José Courty, Yuri Volkov, Adriele Prina-Mello, Angeles Villanueva, Álvaro Somoza, Aitziber L Cortajarena, Rodolfo Miranda, Ingrid Hilger
Breast Cancer Research, 2015, 17, 1-17.
Gold-Coated Superparamagnetic Nanoparticles for Single Methyl Discrimination in DNA Aptamers
Maria Tintoré, Stefania Mazzini, Laura Polito, Marcello Marelli, Alfonso Latorre, Álvaro Somoza, Anna Aviñó, Carme Fàbrega, Ramon Eritja
International journal of molecular sciences, 2015, 16, 27625-27639.
Designed modular proteins as scaffolds to stabilize fluorescent nanoclusters (Highlighted in Biofísica Magazine)
Pierre Couleaud, Sergio Adan-Bermudez, Antonio Aires, Sara H Mejías, Begoña Sot, Alvaro Somoza, Aitziber L Cortajarena
Biomacromolecules, 2015, 16, 3836-3844.
Detection of GNAQ Mutations and Reduction of Cell Viability in Uveal Melanoma Cells with Functionalized Gold Nanoparticles
Christian Posch, Alfonso Latorre, Michelle B. Crosby, Anna Celli, Ana Latorre, Igor Vujic, Martina Sanlorenzo, Gary A. Green, Jingly Weier, Mitchell Zekhtser, Jeffrey Ma, Gabriela Monico, Devron H. Char, Denis Jusufbegovic, Klemens,Rappersberger, Álvaro Somoza, Susana Ortiz-Urda
Biomedical Microdevices, 2015, 17, 1-9.
Glutathione-Triggered Drug Release From Nanostructures
Alfonso Latorre, Álvaro Somoza
Current Topics in Medicinal Chemistry, 2014, 14, 2662-2671.
Multifunctionalization of magnetic nanoparticles for controlled drug release: a general approach
Alfonso Latorre, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, Álvaro Somoza
Eur. J. Med. Chem. 2014, 82, 355–362.
Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening
Miguel Garavís, Blanca López-Méndez, Alvaro Somoza, Julen Oyarzabal, Claudio Dalvit, Alfredo Villasante, Ramón Campos-Olivas, and Carlos González
ACS Chem. Biol., 2014, 9, 1559–1566
DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics
Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza
Nanoscale, 2014, 6, 7436–7442.
Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures.
Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza.
Chem. Commun., 2014, 50, 3018-3020
Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions
S. Pérez-rentero, A. Somoza, S. Grijalvo, B. Martin, I. G. Stará, I. Starý, R. Eritja
Journal of Chemistry, Volume 2013 (2013), Article ID 650610, 11 pages
Fluorescent DNA Stabilized Silver Nanoclusters as biosensors
Alfonso Latorre, Romina Lorca, Álvaro Somoza
Journal of Chemistry, Volume 2013 (2013), Article ID 631421, 6 pages
Enhanced Fluorescence of Silver Nanoclusters Stabilized with Branched Oligonucleotides.
Alfonso Latorre, Romina Lorca, Félix Zamora and Álvaro Somoza
Chem. Commun., 2013, 49, 4950
Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities.
Lourdes I. Cabrera, Álvaro Somoza, José F. Marco, Carlos J. Serna, M. Puerto Morales.
Journal of Nanoparticle Research, 2012, 14, 873.
DNA-mediated silver nanoclusters: synthesis, properties and applications.
Alfonso Latorre, Álvaro Somoza
ChemBioChem., 2012, 13, 951–8.
Interstrand interactions on DNA duplexes modified by TTF units at the 3′ or 5′-ends.
S. Pérez-Rentero, I. Gállego, Á. Somoza, R. Ferreira, J. Janoušek, M. Bělohradský, I. G. Stará, I. Starý, R. Eritja
RSC Advances, 2012, 2, 4069.
RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development. Edited by Paul H. Johnson
Álvaro Somoza.
ChemMedChem, 2011, 6, 1311–1312.
Modified siRNAs for the study of the PAZ domain
Álvaro Somoza, Montserrat Terrazas, Ramón Eritja.
Chemical Commun., 2010, 46, 4270–2
Modificaciones Químicas en ARN interferente: De la investigación básica a las aplicaciones terapéuticas.
Álvaro Somoza
Anales de Química, 2010, 106, 215-222.
Evolution of DNA origami.
Álvaro Somoza
Angew. Chem. Int. Ed., 2009, 48, 9406–8.
Protecting groups for RNA synthesis: an increasing need for selective preparative methods (Selected for its inclusion in RSC’s Chemical Biology issue 1, 2009)
Álvaro Somoza
Chem. Soc. Rev., 2008, 37, 2668-2675
The Roles of Hydrogen Bonding and Sterics in RNA Interference (Hot Paper)
Alvaro Somoza, Jijumon Chelliserrykattil, Eric T. Kool
Angew. Chem. Int. Ed., 2006, 45, 4994–4997.
β-Hydroxysulfoxides as chiral cyclic ketone equivalents: enantioselective synthesis of polysubstituted cyclohexanones, cyclohexenones and cyclohexenediones.
M. Carmen Carreño, Manuel Pérez-González, María Ribagorda, Álvaro Somoza, Antonio Urbano
Chem. Commun., 2002, 3052-3053.
Enantioselective Total Synthesis of Angucyclinone-Type Antibiotics Rubiginones A2 and C2
M. Carmen Carreño, María Ribagorda, Álvaro Somoza, Antonio Urbano
Angew. Chem. Int. Ed., 2002, 41, 2755–2757.
NanoBiotechnology Research Group 