New Approaches to Tackle EMT and Fibrosis: From Epigenetics to Nanotechnology

Cecilia Battistelli, Marco Cordani, Marc Diederich, Álvaro Somoza, Sergio Valente, Raffaele Strippoli

Frontiers in Pharmacology, 2022


Rational Design of Copper (II)–Uracil Nanoprocessed Coordination Polymers to Improve Their Cytotoxic Activity in Biological Media

Verónica G Vegas, Ana Latorre, María Luisa Marcos, Carlos J Gómez-García, Oscar Castillo, Félix Zamora, Jacobo Gómez, José Martínez-Costas, Miguel Vazquez Lopez, Álvaro Somoza, Pilar Amo-Ochoa

ACS Applied Materials & Interfaces 13 (31), 36948-36957


Albumin-based nanostructures for uveal melanoma treatment

Ana Latorre, Alfonso Latorre, Milagros Castellanos, Nuria Lafuente-Gómez, Ciro Rodriguez Diaz, Alejandra Crespo-Barreda, Mercedes Lecea, Marco Cordani, Pilar Martín-Duque, Álvaro Somoza

Nanomedicine: Nanotechnology, Biology and Medicine 35, 102391


Smart Modification on Magnetic Nanoparticles Dramatically Enhances Their Therapeutic Properties

Nuria Lafuente-Gómez, Paula Milán-Rois, David García-Soriano, Yurena Luengo, Marco Cordani, Hernán Alarcón-Iniesta, Gorka Salas, Álvaro Somoza

Cancers 13 (16), 4095


The Role of LncRNAsin Uveal Melanoma

Paula Milán-Rois, Anan Quan, Frank J Slack, Álvaro Somoza

Cancers 13 (16), 4041


Albumin Nanostructures for Nucleic Acid Delivery in Cancer: Current Trend, Emerging Issues, and Possible Solutions

Rama Prajapati, Álvaro Somoza

Cancers 13 (14), 3454


Albumin-Based Nanoparticles for the Delivery of Doxorubicin in Breast Cancer

Rama Prajapati, Eduardo Garcia-Garrido, Álvaro Somoza

Cancers 13 (12), 3011


Novel Cancer Treatments Based on Autophagy Modulation

Marco Cordani, Álvaro Somoza, Marco Tafani, Ilaria Dando, Suresh Kumar

Frontiers in Pharmacology 12


Water soluble iron-based coordination trimers as synergistic adjuvants for pancreatic cancer

Marco Cordani, Esther Resines-Urien, Arturo Gamonal, Paula Milán-Rois, Lionel Salmon, Azzedine Bousseksou, Jose Sanchez Costa, Álvaro Somoza

Antioxidants 10 (1), 66


The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

David García-Soriano, Rebeca Amaro, Nuria Lafuente-Gómez, Paula Milán-Rois, Álvaro Somoza, Cristina Navío, Fernando Herranz, Lucía Gutiérrez, Gorka Salas

Journal of Colloid and Interface Science 578, 510-521


Tailored functionalized magnetic nanoparticles to target breast cancer cells including cancer stem-like cells

Ana Lazaro-Carrillo, Macarena Calero, Antonio Aires, Aitziber L Cortajarena, Bruno M Simões, Alfonso Latorre, Álvaro Somoza, Robert B Clarke, Rodolfo Miranda, Angeles Villanueva

Cancers 12 (6), 1397


Iron Oxide nanoparticles as carriers for DOX and magnetic hyperthermia after intratumoral application into breast cancer in mice: Impact and future perspectives

Susann Piehler, Heidi Dähring, Julia Grandke, Julia Göring, Pierre Couleaud, Antonio Aires, Aitziber L Cortajarena, José Courty, Alfonso Latorre, Álvaro Somoza, Ulf Teichgräber, Ingrid Hilger

Nanomaterials 10 (6), 1016


Boron Dipyrromethene (BODIPY) as Electron‐Withdrawing Group in Asymmetric Copper‐Catalyzed [3+ 2] Cycloadditions for the Synthesis of Pyrrolidine‐Based Biological Sensors

Thomas Rigotti, Juan Asenjo‐Pascual, Ana Martín‐Somer, Paula Milán Rois, Marco Cordani, Sergio Díaz‐Tendero, Álvaro Somoza, Alberto Fraile, Jose Aleman

Advanced Synthesis & Catalysis 362 (6), 1345-1355


Nanomaterials for Autophagy-Related miRNA-34a Delivery in Cancer Treatment

Priyanka Sharma, Ilaria Dando, Raffaele Strippoli, Suresh Kumar, Alvaro Somoza, Marco Cordani, Marco Tafani

Frontiers in Pharmacology 11


Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

Marco Cordani, Raffaele Strippoli, Álvaro Somoza

Cancers 12 (1), 25


Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells

Ana Latorre, Alfonso Latorre, Milagros Castellanos, Ciro Rodriguez Diaz, Ana Lazaro-Carrillo, Tania Aguado, Mercedes Lecea, Sonia Romero-Pérez, Macarena Calero, José María Sanchez-Puelles, Ángeles Villanueva, Álvaro Somoza

Cancers 11 (7), 969


MicroRNA sensors based on gold nanoparticles

Catarina Coutinho, Álvaro Somoza
Anal. Bioanal. Chem.
Read it for free here 

Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment

Marco Cordani, Alvaro Somoza
Cell Mol Life Sci, 2018


Dynamics of Individual Molecular Shuttles Under Mechanical Force

Teresa Naranjo, Kateryna Lemishko, Sd Lorenzo, Alvaro Somoza, Felix Ritort, Emilio Pérez, Borja Ibarra.

Nat. Commun. 9 (1), 4512

Reprogramming Cells for Synergistic Combination Therapy with Nanotherapeutics against Uveal Melanoma

Paula Milán Rois, Alfonso Latorre, Ciro Rodriguez Diaz, Álvaro del Moral, Álvaro Somoza

Biomimetics20183, 28.


Uracil grafted imine-based covalent organic framework for nucleobase recognition

Sergio Royuela, Eduardo García-Garrido, Miguel Martín Arroyo, María J Mancheño, María M Ramos, David González-Rodríguez, Álvaro Somoza, Félix Zamora, José L Segura

Chem. Commun., 2018,54, 8729-8732.


Selective G-quadruplex binding by oligoarginine-Ru (dppz) metallopeptides

David Bouzada, Iria Salvadó, Ghofrane Barka, Gustavo Rama, José Martínez-Costas, Romina Lorca, Álvaro Somoza, Manuel Melle-Franco, M Eugenio Vázquez, Miguel Vázquez López

Chem. Commun., 2018,54, 658-661.


Recent advances in uveal melanoma treatment

Beatriz Álvarez‐Rodríguez, Alfonso Latorre, Christian Posch, Álvaro Somoza

Med. Res. Rev. 201737, 1350-1372


Self-assembly of repeat proteins: Concepts and design of new interfaces.

Sanchez-deAlcazar D, Mejias SH, Erazo K, Sot B, Cortajarena AL.

J Struct Biol. 2017


Mechanical measurement of hydrogen bonded host-guest systems under non-equilibrium, near-physiological conditions (Highlighted in Chemistry World)

Teresa Naranjo, Fernando Cerron, Belén Nieto-Ortega, Alfonso Latorre, Álvaro Somoza, Borja Ibarra, Emilio M Perez

Chem. Sci.2017,8, 6037-604.


Domain topology of human Rasal. 

Cuellar J, Valpuesta JM, Wittinghofer A, Sot B.

Biol Chem. 2017


Oligonucleotide Sensor Based on Selective Capture of Upconversion Nanoparticles Triggered by Target-Induced DNA Interstrand Ligand Reaction

Diego Mendez-Gonzalez, Marco Laurenti, Alfonso Latorre, Alvaro Somoza, Ana Vazquez, Ana Isabel Negredo, Enrique López-Cabarcos, Oscar G Calderón, Sonia Melle, Jorge Rubio-Retama

ACS Appl. Mater. Interfaces20179, 112272-12281.


The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction. 

Sot B, Rubio-Muñoz A, Leal-Quintero A, Martínez-Sabando J, Marcilla M, Roodveldt C, Valpuesta JM.

Sci Rep. 2017;7:40859.


Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers  (Highlighted in Biofísica Magazine

Verónica G Vegas, Romina Lorca, Ana Latorre, Khaled Hassanein, Carlos J Gómez‐García, Oscar Castillo, Álvaro Somoza, Félix Zamora, Pilar Amo‐Ochoa

Angew. Chem. In. Ed. 201756, 987-991.


Molecular chaperones: functional mechanisms and nanotechnological applications. 

Fernández-Fernández MR, Sot B, Valpuesta JM.

Nanotechnology. 2016;27(32):324004.


Controlled nanometric fibers of self-assembled designed protein scaffolds.

Mejías SH, Sot B, Guantes R, Cortajarena AL. 2014; 6(19):10982-8.


Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes.

Sot B, Behrmann E, Raunser S, Wittinghofer A.

Proc Natl Acad Sci U S A. 2013; 110(1):111-6.


Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence (Highlighted in Biofísica Magazine)

Siamak Javani, Romina Lorca, Alfonso Latorre, Cristina Flors, Aitziber L. Cortajarena, and Álvaro Somoza

ACS Appl. Mater. Interfaces20168, 10147–10154.


Modified RNAs in CRISPR/Cas9: An Old Trick Works Again  (Highlighted in Biofísica Magazine)

Alfonso Latorre, Ana Latorre, Álvaro Somoza

Angew. Chem. In. Ed. 2016, 55, 3548–3550.


Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.

Antonio Aires, Sandra M Ocampo, Bruno M Simões, María Josefa Rodríguez, Jael F Cadenas, Pierre Couleaud, Katherine Spence, Alfonso Latorre, Rodolfo Miranda, Álvaro Somoza, Robert B Clarke, José L Carrascosa, Aitziber L Cortajarena.

Nanotechnology, 201627, 065103.


Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery 

Susanne Kossatz, Julia Grandke, Pierre Couleaud, Alfonso Latorre, Antonio Aires, Kieran Crosbie-Staunton, Robert Ludwig, Heidi Dähring, Volker Ettelt, Ana Lazaro-Carrillo, Macarena Calero, Maha Sader, José Courty, Yuri Volkov, Adriele Prina-Mello, Angeles Villanueva, Álvaro Somoza, Aitziber L Cortajarena, Rodolfo Miranda, Ingrid Hilger

Breast Cancer Research, 201517, 1-17.


Gold-Coated Superparamagnetic Nanoparticles for Single Methyl Discrimination in DNA Aptamers 

Maria Tintoré, Stefania Mazzini, Laura Polito, Marcello Marelli, Alfonso Latorre, Álvaro Somoza, Anna Aviñó, Carme Fàbrega, Ramon Eritja

International journal of molecular sciences, 201516, 27625-27639.


Designed modular proteins as scaffolds to stabilize fluorescent nanoclusters  (Highlighted in Biofísica Magazine)

Pierre Couleaud, Sergio Adan-Bermudez, Antonio Aires, Sara H Mejías, Begoña Sot, Alvaro Somoza, Aitziber L Cortajarena

Biomacromolecules, 201516, 3836-3844.


Detection of GNAQ Mutations and Reduction of Cell Viability in Uveal Melanoma Cells with Functionalized Gold Nanoparticles 

Christian Posch, Alfonso Latorre, Michelle B. Crosby, Anna Celli, Ana Latorre, Igor Vujic, Martina Sanlorenzo, Gary A. Green, Jingly Weier, Mitchell Zekhtser, Jeffrey Ma, Gabriela Monico, Devron H. Char, Denis Jusufbegovic, Klemens,Rappersberger, Álvaro Somoza, Susana Ortiz-Urda

Biomedical Microdevices, 201517, 1-9.


Glutathione-Triggered Drug Release From Nanostructures 

Alfonso Latorre, Álvaro Somoza

Current Topics in Medicinal Chemistry2014, 14, 2662-2671.


Multifunctionalization of magnetic nanoparticles for controlled drug release: a general approach

Alfonso Latorre, Pierre Couleaud, Antonio Aires, Aitziber L. Cortajarena, Álvaro Somoza

Eur. J. Med. Chem. 201482, 355–362.


Discovery of selective ligands for telomeric RNA G-quadruplexes (TERRA) through 19F-NMR based fragment screening

Miguel Garavís, Blanca López-Méndez, Alvaro Somoza, Julen Oyarzabal, Claudio Dalvit, Alfredo Villasante, Ramón Campos-Olivas, and Carlos González

ACS Chem. Biol.20149, 1559–1566


DNA and aptamer stabilized gold nanoparticles for targeted delivery of anticancer therapeutics

Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza

Nanoscale, 20146, 7436–7442.


Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures.

Alfonso Latorre, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza.

Chem. Commun.201450, 3018-3020


Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions

S. Pérez-rentero, A. Somoza, S. Grijalvo, B. Martin, I. G. Stará, I. Starý, R. Eritja

Journal of Chemistry, Volume 2013 (2013), Article ID 650610, 11 pages


Fluorescent DNA Stabilized Silver Nanoclusters as biosensors

Alfonso Latorre, Romina Lorca, Álvaro Somoza

Journal of Chemistry, Volume 2013 (2013), Article ID 631421, 6 pages


Enhanced Fluorescence of Silver Nanoclusters Stabilized with Branched Oligonucleotides.

Alfonso Latorre, Romina Lorca, Félix Zamora and Álvaro Somoza

Chem. Commun., 2013, 49, 4950


Synthesis and surface modification of uniform MFe2O4 (M = Fe, Mn, and Co) nanoparticles with tunable sizes and functionalities. 

Lourdes I. Cabrera, Álvaro Somoza, José F. Marco, Carlos J. Serna, M. Puerto Morales.

Journal of Nanoparticle Research, 2012, 14, 873.


DNA-mediated silver nanoclusters: synthesis, properties and applications.

Alfonso Latorre, Álvaro Somoza

ChemBioChem., 2012, 13, 951–8.


Interstrand interactions on DNA duplexes modified by TTF units at the 3′ or 5′-ends.

S. Pérez-Rentero, I. Gállego, Á. Somoza, R. Ferreira, J. Janoušek, M. Bělohradský, I. G. Stará, I. Starý, R. Eritja

RSC Advances, 2012, 2, 4069.


RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development. Edited by Paul H. Johnson

Álvaro Somoza.

ChemMedChem, 2011, 6, 1311–1312.


Modified siRNAs for the study of the PAZ domain

Álvaro Somoza, Montserrat Terrazas, Ramón Eritja.

Chemical Commun., 2010, 46, 4270–2


Modificaciones Químicas en ARN interferente: De la investigación básica a las aplicaciones terapéuticas.

Álvaro Somoza

Anales de Química, 2010, 106, 215-222.


Evolution of DNA origami.

Álvaro Somoza

Angew. Chem. Int. Ed., 2009, 48, 9406–8.


Protecting groups for RNA synthesis: an increasing need for selective preparative methods (Selected for its inclusion in RSC’s Chemical Biology issue 1, 2009)

Álvaro Somoza

Chem. Soc. Rev., 2008, 37, 2668-2675


The Roles of Hydrogen Bonding and Sterics in RNA Interference (Hot Paper)

Alvaro Somoza, Jijumon Chelliserrykattil, Eric T. Kool

Angew. Chem. Int. Ed., 2006, 45, 4994–4997.


β-Hydroxysulfoxides as chiral cyclic ketone equivalents: enantioselective synthesis of polysubstituted cyclohexanones, cyclohexenones and cyclohexenediones. 

M. Carmen Carreño, Manuel Pérez-González, María Ribagorda, Álvaro Somoza, Antonio Urbano

Chem. Commun., 2002, 3052-3053.


Enantioselective Total Synthesis of Angucyclinone-Type Antibiotics Rubiginones A2 and C2

M. Carmen Carreño, María Ribagorda, Álvaro Somoza, Antonio Urbano

Angew. Chem. Int. Ed., 2002, 41, 2755–2757.